Author(s)

ZhanLiang Wei, JianRong Huang^*, Jie Bin, Feng Lai

Affiliation(s)

Department of Neurosurgery, Nanning Second People's Hospital of Guangxi, Nanning 530031, Guangxi, China.

Corresponding Author

JianRong Huang

ABSTRACT

Objective: To explore the clinical efficacy and safety of early interventional embolization in the treatment of ruptured anterior communicating artery aneurysms. Given the current controversy regarding the timing of interventional embolization, this study aims to provide a basis for optimizing treatment strategies. Methods: A retrospective analysis was conducted on 22 patients with ruptured anterior communicating artery aneurysms admitted to the interventional center of a hospital from January 2024 to February 2024. Patients were divided into the experimental group (interventional embolization within 72 hours of onset, n=11) and the control group (interventional embolization after 72 hours of onset, n=11) based on the timing of treatment. Data were collected on surgical success rate, complications, and neurological prognosis. Statistical analysis was performed using χ2 test and t-test. Results: The surgical success rate in the experimental group (100%) was significantly higher than in the control group (81.8%, P < 0.05). The incidence of severe complications such as severe pneumonia and hydrocephalus in the experimental group (9.1%) was significantly lower than in the control group (36.4%, P < 0.05). The mRS score at 6-month follow-up in the experimental group (1.42 ± 0.9) was better than that in the control group (2.15 ± 1.8, P < 0.05); the proportion of patients with mRS score ≤ 2 at 6-month follow-up in the experimental group (90.9%) was higher than that in the control group (72.7%, P < 0.05). These findings are consistent with previous studies that have shown early interventional embolization can significantly improve the surgical success rate, reduce the risk of complications, and improve the neurological prognosis of patients with ruptured anterior communicating artery aneurysms.Conclusion: Early interventional embolization in the treatment of ruptured anterior communicating artery aneurysms can significantly improve the surgical success rate, reduce the risk of complications, and improve the neurological prognosis. This study provides important evidence for optimizing treatment strategies.

KEYWORDS

Anterior communicating artery aneurysm; Interventional embolization; Early treatment; Treatment outcome; Single-center study

CITE THIS PAPER

ZhanLiang Wei, JianRong Huang, Jie Bin, Feng Lai. Early versus delayed interventional embolization for ruptured anterior communicating artery aneurysms: a single-center retrospective cohort study of 22 cases with literature review. Journal of Pharmaceutical and Medical Research. 2025, 7(2): 14-18. DOI: https://doi.org/10.61784/jpmr3039.

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