Author(s)

Shailesh B. Patel

Affiliation(s)

Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Corresponding Author

Shailesh B. Patel

ABSTRACT

The mRNA levels of genes for lipid lipogenesis as well as other genesare quantified in the brain of Abcg4 knockout and wild type littermates usingquantitative RT-PCR, The results showed that diferent sets of genes for lipidmetabolism were activated in the brains of Abcg4 -/- male and female mice, whencompared to those of the wild type counterparts. It is shown that Abcg4 is a sexregulated gene with the function of diferentially regulating fatty acid and/orcholesterol synthesis in the brain.

KEYWORDS

ATP-Binding Cassette transporter (ABC); Abcg4; Cholesterol; Lipogenesis; Gene knockout mouse; Quantitative PCR; Brain

CITE THIS PAPER

Shailesh B. Patel. Gender-Specific Effect of Deficientabcg4 on Lipogenesis in a Mouse's Brain. Acta Translational Medicine. 2018, 1(1): 1-7.

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