Author(s)

Guo-Jie Wang^1# , Le-Wei Yang^2# , Shi-Rui Yang^3# , Bin Zhou⁴ , Run-Gen Zhan⁵ , Ya-Li Zhang⁶, Yong-Jun Peng^5*, Jie Zhang^5*

Affiliation(s)

^1.Department of Radiology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China

^2.Department of Abdominal Oncology, The Cancer Center of The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, China

^3.Department of Nuclear Medicine, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China

^4.Department of Pathology, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000,

China

^5.Department of Radiology, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China

^6.Xindian health center, SuiDe 718000, China

Corresponding Author

Yong-Jun Peng, Jie Zhang

ABSTRACT

Objective: To compare three-dimensional (3D) volume measurement versus two-dimensional (2D) measurement during MR assessment of pre-treatment locally advanced cervical cancer, and to investigate the association of measurement outcomes with the staging of the tumor and histopathological feature in locally advanced cervical cancer. Methods: 46 patients were found having locally advanced cervical cancer that was confirmed by pathology (39 squamous cell carcinoma,7 adenomatous carcinoma). All patients were scanned by conventional MR scan, DCE-MR, and DWI sequence. Measurement results were compared between normal tissues and cervical cancer tissues in 3D and 2D. The association of measurement outcomes of 3D and 2D with the pathological grade and clinical stage of cervical cancer was explored. Results: There was no statistically significant difference between the results of 3D volume measurements and 2D diameter measurements (P>0.05). A significant correlation was found between the 3D volume measurement and cervical cancer stages (P<0.05). There was no correlation between 2D measurements and the clinical stage of cervical cancer (P>0.05). The outcomes between 3D volume measurement and 2D diameter measurement(The short cross-sectional diameter) among different histopathological grading of cervical cancer had statistical significance (P<0.05). Conclusion:3D volume measurement is more effective compared with 2D diameter measurement in MR assessment of locally advanced cervical cancer. In locally advanced cervical cancer, 3D volume measuring correlates with pathological grading and clinical stage. It provides more accurate and comprehensive data on pre-treatment cervical cancer. Therefore, 3D volume measurement can be used in preoperative MR imaging to monitor response to therapy and improve radiomics features analysis in patients with locally advanced cervical cancer.

KEYWORDS

 Cervical cancer, Locally advanced cancer, MR imaging, Tumor stage

CITE THIS PAPER

Guo-Jie Wang, Le-Wei Yang, Shi-Rui Yang, Bin Zhou, Run-Gen Zhan, Ya-Li Zhang, Yong-Jun Peng, Jie Zhang. Comparison of the diagnostic performance of 2d and 3d mr images in staging and histopathology findings of locally advanced cervical cancer. Acta Translational Medicine. 2022, 5(1): 8-14.

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