PATIENTS INFECTED WITH THE OMICRON VARIANT OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2: INITIAL CHEST CT FINDINGS AND TEMPORAL CHANGES
Volume 6, Issue 1, Pp 6-10, 2023
DOI: 10.61784/ActaMed230516
Author(s)
Xiaobin Liu#, Junqi Luo#, Peixin Qin, Lanfang Huang, Meizi Qu, Guojie Wang*, Binghui Chen*
Affiliation(s)
Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Corresponding Author
Guojie Wang, Binghui Chen
ABSTRACT
Background: Omicron has higher transmissivity compared to previous strains, and clinical manifestations are not identical. To date, few studies have examined the imaging characteristics of Omicron. Methods: The patients undergo one or more CT examinations. The radiologist analyzed abnormal lung patterns and how these characteristics changed over time. Results: 18 patients (4.9%, 18/364) had viral pneumonia on chest CT, 14 had follow-up CT, and 11 had three or more CT examinations. 11 patients (11/14) had the most lung segments affected by pneumonia at the initial CT and then decreased. Three patients (3/14) had fewer lung segments affected by pneumonia during the first CT examinations, and the number increased during the follow-up CT, two were elderly with basic diseases and unvaccinated. Ground-glass opacity (GGO) was the primary abnormality at the first CT in seven patients (7/11). Then GGO decreased, and mixed lesions appeared in two patients. On the third CT, 5 patients showed complete absorption of pneumonia (5/11), and the residual lesions were pure GGO (2/11) or mixed GGO (4/11). Conclusion: Pneumonia is rare in patients with Omicron and is absorbed quickly, but pneumonia lasts longer in patients with underlying illnesses or those who are older.
KEYWORDS
COVID-19; Omicron; CT
CITE THIS PAPER
Xiaobin Liu, Junqi Luo, Peixin Qin, Lanfang Huang, Meizi Qu, Guojie Wang, Binghui Chen. Patients infected with the omicron variant of severe acute respiratory syndrome Coronavirus 2: initial chest CT findings and temporal changes. Acta Translational Medicine. 2023, 6(1): 6-10.
REFERENCES
[1] World Health Organization: WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/.
[2] World Health Organization (WHO): What you need to know about the new Omicron COVID-19 variant. https://www.who.int/europe/news/item/03-12-2021- what-you-need-to-know-about-the-new-omicron-co vid-19-variant
[3] Chen J, Wang R, Gilby NB, et al. Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance. J Chem Inf Model. 2022 Jan 24;62(2):412-422. DOI: 10.1021/acs.jcim.1c01451.
[4] Meo SA, Meo AS, Al-Jassir FF, et al. Omicron SARS-CoV-2 new variant: global prevalence and biological and clinical characteristics. Eur Rev Med Pharmacol Sci. 2021 Dec;25(24):8012-8018. DOI: 10.26355/eurrev_202112_27652.
[5] Callaway E, Ledford H. How bad is Omicron? What scientists know so far. Nature. 2021 Dec;600(7888):197-199. DOI: 10.1038/d41886-021-03614-z.
[6] Gao SJ, Guo H, Luo G. Omicron variant (B.1.1.529) of SARS-CoV-2, a global urgent public health alert! J Med Virol. 2022 Apr;94(4):1255-1256. DOI: 10.1002/jmv.27491.
[7] Tsakok MT, Watson RA, Saujani SJ, et al. Reduction in Chest CT Severity and Improved Hospital Outcomes in SARS-CoV-2 Omicron Compared with Delta Variant Infection. Radiology. 2023 Jan;306(1):261-269. doi: 10.1148/radiol.220533.
[8] Yoon SH, Lee JH, Kim BN. Chest CT Findings in Hospitalized Patients with SARS-CoV-2: Delta versus Omicron Variants. Radiology. 2023 Jan;306(1):252-260. doi: 10.1148/radiol.220676.
[9] Hansell DM, Bankier AA, MacMahon H, et al. Fleischner Society: glossary of terms for thoracic imaging. Radiology 2008;246(3):697-722. DOI: 10.1148/radiol.2462070712
[10] Ooi GC, Khong PL, Muller NL, et al. Severe acute respiratory syndrome: temporal lung changes at10 Patients infected with the omicron variant of severe acute respiratory syndrome coronavirus 2 ?M&H ACADEMIC PUBLISHER DOI: 10.61784/ActaMed230516 thin-section CT in 30 patients. Radiology 2004;230(3):836-844. DOI: 10.1148/radiol.2303030853.
[11] Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. DOI: 10.1056/NEJMoa2002032.
[12] Wang Y, Dong C, Hu Y, et al. Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study. Radiology. 2020 Aug;296(2):E55-E64. doi: 10.1148/radiol.2020200843. Epub 2020 Mar 19. PMID: 32191587; PMCID: PMC7233482.
[13] Liu J, Zhang L, Yan Y, et al. Excess mortality in Wuhan city and other parts of China during the three months of the covid-19 outbreak: findings from nationwide mortality registries. BMJ. 2021 Feb 24;372:n415. DOI: 10.1136/bmj.n415. PMID: 33627311; PMCID: PMC7900645.
[14] Chung M, Bernheim A, Mei X, et al. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020 Apr;295(1):202-207. DOI: 10.1148/radiol.2020200230.
[15] Xiong Y, Sun D, Liu Y, et al. Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes. Invest Radiol. 2020 Jun;55(6):332-339. DOI: 10.1097/RLI.0000000000000674.
[16] Li X, Zeng W, Li X, et al. CT imaging changes of coronavirus disease 2019(COVID-19): a multi-center study in Southwest China. J Transl Med. 2020 Apr 6;18(1):184. DOI: 10.1186/s12967-020-02324-w.
[17] Zhou S, Zhu T, Wang Y, et al. Imaging features and evolution on CT in 100 COVID-19 pneumonia patients in Wuhan, China. Eur Radiol. 2020 Oct;30(10):5446-5454. DOI: 10.1007/s00330-020-06879-6.
[18] Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. Eur Radiol. 2020 Jun;30(6):3306-3309. DOI: 10.1007/s00330-020-06731-x.