Author(s)

HaoDi Fu, YiHuan Chen^*

Affiliation(s)

Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.

Corresponding Author

YiHuan Chen

ABSTRACT

Cardiac repair after acute myocardial infarction depends on the precise regulation of the immune microenvironment. Macrophages are now understood beyond the M1/M2 dichotomy, with dual origins and a continuous functional spectrum. This review summarizes the spatiotemporal roles of cardiac resident and monocyte-derived macrophages, as well as their coordination in the resolution of inflammation, tissue repair, and scar maturation. It also outlines new therapeutic strategies targeting the recruitment of macrophages, their phenotypic transition, and metabolic reprogramming to improve post-infarction cardiac remodeling.

KEYWORDS

Myocardial infarction; Macrophages; Ventricular remodeling; Immunotherapy

CITE THIS PAPER

HaoDi Fu, YiHuan Chen. Macrophages in acute myocardial infarction: heterogeneity and targeted therapies. Journal of Pharmaceutical and Medical Research. 2025, 7(3): 61-70. DOI: https://doi.org/10.61784/jpmr3058.

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